Expired air carbon monoxide concentration in mothers and their spouses above 5 ppm is associated with decreased fetal growth.

Background: Smoking during pregnancy is associated with reduced birthweight; this relation can be reversed by smoking cessation. Some but not all previous studies have shown that smoking reduction (measured as cigarettes/day or urinary cotinine) may also improve birthweight. The relationship between maternal and spouses' expired air carbon monoxide (CO) concentrations (EACO) on fetal growth has not yet been evaluated.

Aspirin (100 mg) used for prevention of pre-eclampsia in nulliparous women: the Essai Régional Aspirine Mère-Enfant study (Part 1).

Objective: To reduce the incidence of pre-eclampsia in nulliparous women, in accordance with the suggestion of a recent meta-analysis that low dose aspirin might decrease this incidence by more than half if used early enough in and at a sufficient dose during pregnancy (more than 75 mg).

Design: Multicentre randomised double-blinded placebo-controlled trial.

Setting: Twenty eight centres in Northern of France and one in Belgium.