The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers.

The aim of this study was to establish a correlation between carrier characteristics and the dispersibility of drug from the blend. The influence of the roughness of a commonly used carrier material, lactose monohydrate, on the adhesion, dose uniformity, and aerodynamic properties of a model drug, terbutaline sulphate was investigated. Evaluation of adhesion was carried out with a mechanical sieve and an Alpine air-jet sieve.

Study of talcs as antisticking agents in the production of tablets.

Talc is defined as a crystalline structure characteristic of lamellar structures. Antisticking power varies according to the talc considered. Besides chemical properties, it is necessary to assess physical properties related to functionality.