Prospective comparison of F-NaF PET/CT versus F-FDG PET/CT imaging in mandibular extension of head and neck squamous cell carcinoma with dedicated analysis software and validation with surgical specimen. A preliminary study.

Background: The aim of this study is to propose a new method to quantify radioactivity with PET/CT imaging in mandibular extension in head and neck squamous cell carcinoma (HNSCC), using innovative software, and to compare results with microscopic surgical specimens.

Patients And Methods: This prospective study enrolled 15 patients who underwent F-NaF and F-FDG PET/CT. We compared the delineations of bone invasions obtained with F-NaF PET/CT and F-FDG PET/CT with the results of histopathological analysis of mandibular resections (from right and left bone borders).

Evaluation of O-(2-[18F]-Fluoroethyl)-L-Tyrosine in the Diagnosis of Glioblastoma.

Objective: To assess the feasibility of synthesis of O-(2-[(18)F]-fluoroethyl)-l-tyrosine (FET), a new positron emission tomographic (PET) tracer described in several studies but not yet considered standard in management of glioma, in routine practice and to determine FET uptake in a homogeneous group of patients with suspected high-grade glioma.

Design: Prospective nonrandomized trial.

Patients: Twelve patients with suspicion of high-grade glioma.

[Does tobacco smoking induce significant artificial irradiation?].

Artificial irradiation due to tobacco smoking is a widely accepted phenomenon, but the possible health implications are controversial. The IAEA has estimated that smoking twenty cigarettes a day induces a total "radiation exposure" of 53 mSv, but several other authors have estimated that the effective dose is only about 0.4 mSv/year.

Iterative three-dimensional expectation maximization restoration of single photon emission computed tomography images: application in striatal imaging.

Single photon emission computed tomography imaging suffers from poor spatial resolution and high statistical noise. Consequently, the contrast of small structures is reduced, the visual detection of defects is limited and precise quantification is difficult. To improve the contrast, it is possible to include the spatially variant point spread function of the detection system into the iterative reconstruction algorithm.

Multimodal image registration for localization of sentinel nodes in head and neck squamous cell carcinoma.

Purpose: The aim of this clinical study was to propose a new method of preoperative 3-dimensional localization of the neck sentinel node in clinically and radiographically N0 squamous cell carcinoma of the oral cavity.

Patients And Methods: This prospective study was carried out between August 2002 and August 2003. Ten patients with staged oral squamous cell cancer underwent this method of preoperative localization of the sentinel lymph node.