A novel lung SBRT treatment planning: Inverse VMAT plan with leaf motion limitation to ensure the irradiation reproducibility of a moving target.

This study exposed the implementation of a novel technique (VMAT) for the planning of moving targets in lung stereotactic body radiation therapy (SBRT). This new technique has been compared to static conformal radiotherapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and dynamic conformal arc (DCA). The rationale of this study was to lower geometric complexity (54.

Dosimetric comparison of VMAT standard optimization (SO) and multi-criteria optimization (MCO) treatment plans with standard mode delivery (STD) or sliding window (SW) for head and neck cancer.

Purpose: A new development on the RayStation treatment planning system (TPS) allows a plan to be planned by imposing a constraint on the leaf sequencing: all leaves move in the same direction before moving again in the opposite direction to create a succession of sliding windows (SWs). The study aims to investigate this new leaf sequencing, coupled with standard optimization (SO) and multi-criteria optimization (MCO) and to compare it with the standard sequencing (STD).

Methods: Sixty plans were replanned for 10 head and neck cancer patients (two dose levels simultaneously SIB, 56 and 70 Gy in 35 fractions).

Synthetic computed tomography generation for abdominal adaptive radiotherapy using low-field magnetic resonance imaging.

Background And Purpose: Magnetic Resonance guided Radiotherapy (MRgRT) still needs the acquisition of Computed Tomography (CT) images and co-registration between CT and Magnetic Resonance Imaging (MRI). The generation of synthetic CT (sCT) images from the MR data can overcome this limitation. In this study we aim to propose a Deep Learning (DL) based approach for sCT image generation for abdominal Radiotherapy using low field MR images.

Characterisation of a split gradient coil design induced systemic imaging artefact on 0.35 T MR-linac systems.

. The aim of this work was to highlight and characterize a systemic 'star-like' artefact inherent to the low field 0.35 T MRIdian MR-linac system, a magnetic resonance guided radiotherapy device.

Nano-Structuration of WO Nanoleaves by Localized Hydrolysis of an Organometallic Zn Precursor: Application to Photocatalytic NO Abatement.

WO is a known photocatalytic metal oxide frequently studied for its depollution properties. However, it suffers from a high recombination rate of the photogenerated electron/holes pair that is detrimental to its performance. In this paper, we present a new chemical method to decorate WO nanoleaves (NLs) with a complementary metal oxide (ZnWO) in order to improve the photocatalytic performance of the composite material for the abatement of 400 ppb NO under mild UV exposure.

Adaptive Magnetic Resonance-Guided External Beam Radiation Therapy for Consolidation in Recurrent Cervical Cancer.

Purpose: Adaptive magnetic resonance (MR)-guided brachytherapy takes an important place as consolidation within the care of cervical malignancies, but may be impracticable in some unusual cases. This work aimed to present the case of adaptive MR-guided external beam radiation therapy (aMRgRT) used as a boost in a recurrence of cervical cancer.

Methods And Materials: We report on a case of a parametrial recurrence in a 31-year-old patient who already underwent a trachelectomy as treatment for her primary growth.

Grafting Copper Atoms and Nanoparticles on Double-Walled Carbon Nanotubes: Application to Catalytic Synthesis of Propargylamine.

The decoration of carbon nanotubes (CNTs) by metal nanoparticles (NPs) combines the advantages of a high specific surface material with catalytic properties of metal nanocrystals. Little work has been devoted to the decoration of CNTs with copper NPs, and no evidence of copper atomic decoration of CNTs has shown up until now. Herein, we demonstrate that the strong acidic oxidation of double-walled CNTs (dwCNTs) is very efficient for the decoration of the carbon surface by copper NPs and atoms.

Coordination of Ethylamine on Small Silver Clusters: Structural and Topological (ELF, QTAIM) Analyses.

Amine ligands are expected to drive the organization of metallic centers as well as the chemical reactivity of silver clusters early growing during the very first steps of the synthesis of silver nanoparticles an organometallic route. Density functional theory (DFT) computational studies have been performed to characterize the structure, the atomic charge distribution, and the planar two-dimensional (2D)/three-dimensional (3D) relative stability of small-size silver clusters (Ag, 2 ≤ ≤ 7), with or without an ethylamine (EA) ligand coordinated to the Ag clusters. The transition from 2D to 3D structures is shifted from = 7 to 6 in the presence of one EA coordinating ligand, and it is explained from the analysis of the Ag-N and Ag-Ag bond energies.

[Start of activity with the MRIdian® system: The first 200 patients treated at the Institut Paoli-Calmettes].

Introduction: Several centers have recently been equipped with MRI-guided radiotherapy systems, including the Paoli-Calmettes Institute which was the first French center to start this activity. We report in this article our early experience.

Methods: Data related to patients treated on the MRIdian® (Viewray®) were prospectively collected.

Reducing dose to rectum by placement of a rectum-emptying tube in cervical cancer patients treated with brachytherapy.

Purpose: Only scarce data are available on the possibility to reduce rectal dose by controlling rectum filling before HDR (high dose rate) IGABT (image-guided adaptive brachytherapy) in LACC (locally advanced cervical carcinoma) patients. We compared dosimetric outcomes before and after the evacuation of gasses using a rectum emptying tube.

Methods And Material: Sixty CT (computed tomography) scans from 30 consecutive patients with cancer of the cervix undergoing HDR IGABT after EBRT were reviewed.

Topological Analysis of Ag-Ag and Ag-N Interactions in Silver Amidinate Precursor Complexes of Silver Nanoparticles.

A series of silver amidinate complexes has been studied both experimentally and theoretically, in order to investigate the role of the precursor complex in the control of the synthesis of silver nanoparticles via an organometallic route. The replacement of the methyl substituent of the central carbon atom of the amidinate anion by a -butyl group allows for the crystallization of the tetranuclear silver amidinate complex instead of a mixture of di- and trinuclear silver amidinate complexes and , as obtained with a methyl substituent. The relative stabilities and dissociation schemes of various isomeric arrangements of silver atoms in are investigated at the computational DFT level of calculation, depending on the substituents of the amidinate ligand.

Removable Composite Electrode Made of Silver Nanoparticles on Pyrolyzed Photoresist Film for the Electroreduction of 4-Nitrophenol.

Access to removable nanocomposite electrodes for electrosensing of pollutants is of great importance. However, the preparation of reproducible and reliable carbon electrodes decorated with metallic nanoparticles, a prerequisite for trustworthy devices, remains a challenge. Here we describe an innovative and easy method to prepare such electrodes.

The role of alkylamine in the stabilization of CuO nanoparticles as a determinant of the Al/CuO redox reaction.

We report on a new strategy to synthesize Al/CuO nanothermites from commercial Al and ultra-small chemically synthesized CuO nanoparticles coated with alkylamine ligands. These usual ligands stabilize the CuO nanoparticles and prevent them from aggregating, with the goal to enhance the interfacial contact between Al and CuO particles. Using a variety of characterization techniques, including microscopy, spectroscopy, mass spectrometry and calorimetry (ATG/DSC), the structural and chemical evolution of CuO nanoparticles stabilized with alkylamine ligands is analyzed upon heating.

Multivariate normal tissue complication probability modeling of vaginal late toxicity after brachytherapy for cervical cancer.

Purpose: To explore the best variables combination for a predictive model of vaginal toxicity in cervical cancer patients undergoing brachytherapy (BT).

Methods And Materials: Clinical and 3-dimensional dosimetric parameters were retrospectively extracted from an institutional database of consecutive patients undergoing intracavitary BT after external beam radiation therapy from 2006 to 2013 for a cervical cancer. A least absolute shrinkage and selection operator selection procedure in Cox's proportional hazards regression model was performed to select a set of relevant predictors for a multivariate normal tissue complication probability model of Grade ≥2 vaginal late toxicity.

Safety and benefit of using a virtual bolus during treatment planning for breast cancer treated with arc therapy.

Purpose: This study evaluates the benefit of a virtual bolus method for volumetric modulated arc therapy (VMAT) plan optimization to compensate breast modifications that may occur during breast treatment.

Methods: Ten files were replanned with VMAT giving 50 Gy to the breast and 47 Gy to the nodes within 25 fractions. The planning process used a virtual bolus for the first optimization, then the monitors units were reoptimized without bolus, after fixing the segments shapes.

Treatment planning for spinal radiosurgery : A competitive multiplatform benchmark challenge.

Purpose: To investigate the quality of treatment plans of spinal radiosurgery derived from different planning and delivery systems. The comparisons include robotic delivery and intensity modulated arc therapy (IMAT) approaches. Multiple centers with equal systems were used to reduce a bias based on individual's planning abilities.

Controlled Growth and Grafting of High-Density Au Nanoparticles on Zinc Oxide Thin Films by Photo-Deposition.

The integration of high-purity nano-objects on substrates remains a great challenge for addressing scaling-up issues in nanotechnology. For instance, grafting gold nanoparticles (NPs) on zinc oxide films, a major step process for catalysis or photovoltaic applications, still remains difficult to master. We report a modified photodeposition (P-D) approach that achieves tight control of the NPs size (7.

Flattening Filter Free . Flattened Beams for Lung Stereotactic Body Radiation Therapy.

Background/aim: To assess the clinical impact of high dose rate stereotactic body radiation therapy (SBRT) in patients with lung neoplastic lesions.

Patients And Methods: From January 2014 to June 2016, a single-center retrospective analysis was performed including all patients treated by either flattening filter free (FFF) beams or flattening filter beams (FF) three-dimensional (3D) SBRT for lung neoplastic lesions.

Results: A total of 99 SBRT were performed on 75 patients.

Organometallic Synthesis of CuO Nanoparticles: Application in Low-Temperature CO Detection.

A metal-organic approach has been employed for the preparation of anisotropic CuO nanoparticles. These nanostructures have been characterized by transmission and high resolution transmission electron microscopy, field-emission scanning electron microscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The CuO nanoparticles have been deposited as gas-sensitive layers on miniaturized silicon devices.