Publications by authors named "Pierre Duraffour"
Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over.
Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over.
Birdshot chorioretinopathy (BSCR) is a bilateral chronic inflammation of the eye with no extraocular manifestations. BSCR affects middle-aged individuals from European descent and is strongly associated with the human leucocyte antigen (HLA)-A29 allele. The immune mechanisms involved are not fully understood, but recent advances have shown the role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in disease pathogenesis.
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- KP (Klebsiella pneumoniae) is the leading cause of endogenous endophthalmitis (EE) in Asia, and this study looks at eight cases from France, indicating it may be on the rise in Europe.
- Researchers analyzed EE cases from 2014 to 2021, finding that 24% were caused by KP, primarily the hypervirulent strain, with most cases occurring recently.
- Patients with KP EE often had multiple infections outside the eyes, particularly notable liver abscesses, and a significant portion also experienced cerebral complications, with poor visual outcomes for all involved.
Purpose: To describe a case of Vogt-Koyanagi-Harada (VKH) disease after a Covid-19 mRNA vaccine (tozinameran) and to present the results of a pharmacovigilance disproportionality study.
Methods: A retrospective chart review and a pharmacovigilance disproportionality study using the WHO global individual case safety reports database (VigiBase).
Results: A 57-year-old female with no medical history developed a VKH disease 3 weeks after Covid-19 mRNA vaccine.
Objective: Peripheral ulcerative keratitis (PUK) is a rare but severe ocular complication of rheumatoid arthritis (RA). It can be considered as an ocular manifestation of rheumatoid vasculitis (RV). Our case series aimed to evaluate the efficacy of rituximab (RTX) for PUK occurring in patients with RA.
View Article and Find Full Text PDFPurpose: We report the case of a 19-year-old patient who presented with an ocular hypotony due to a transscleral filtration through an isolated congenital chorioretinal coloboma in his right eye.
Observations: The initial examination showed a decimal best corrected visual acuity (BCVA) decreased to 0.7 and a marked hypotony.
Background/objectives: To assess the ratio of scarred/active areas of fundus lesions in patients with presumed ocular toxoplasmosis.
Subjects/methods: Retrospective monocentric study of patients with presumed ocular toxoplasmosis seen between May 2004 and February 2018. Patients with a positive anti-Toxoplasma serology presenting characteristic fundus lesions.