Reconstructing ice-margin retreat using delta morphostratigraphy.

The paleogeographic reconstruction of the successive inland positions of a retreating ice sheet is generally constrained by mapping moraines. However, deltaic complexes constructed by sediment-charged meltwater can also provide a record of the retreating ice-margin positions. Here, we examine a serie of ice-contact, ice-distal glaciofluvial and paraglacial depositional systems that developed along the Québec North Shore (eastern Canada) in the context of falling relative sea level during the northward retreat of the Laurentide Ice Sheet (LIS).

ER-mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem-like cells.

Glioblastoma is a highly heterogeneous aggressive primary brain tumor, with the glioma stem-like cells (GSC) being more sensitive to cytotoxic lymphocyte-mediated killing than glioma differentiated cells (GDC). However, the mechanism behind this higher sensitivity is unclear. Here, we found that the mitochondrial morphology of GSCs modulates the ER-mitochondria contacts that regulate the surface expression of sialylated glycans and their recognition by cytotoxic T lymphocytes and natural killer cells.

Percutaneous vertebroplasty in octogenarians: results and follow-up.

Objectives: To determine pain relief, performance status, morbidity, and mortality associated with percutaneous vertebroplasty for spinal pain in patients aged 80 years and older.

Design: Prospective, descriptive, third-party independent interview, clinical audit.

Setting: University Hospital, Geneva, Switzerland.

High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.

Tumor-reactive T cells play an important role in cancer immunosurveillance. Applying the multimer technology, we report here an unexpected high frequency of Melan-A-specific CTLs in a melanoma patient with progressive lymph node metastases, consisting of 18 and 12.8% of total peripheral blood and tumor-infiltrating CD8+ T cells, respectively.

T-cell immune responses in the brain and their relevance for cerebral malignancies.

In order that cellular immune responses afford protection without risk to sensitive normal tissue, they must be adapted to individual tissues of the body. Nowhere is this more critical than for the brain, where various passive and active mechanisms maintain a state of immune privilege that can limit high magnitude immune responses. Nevertheless, it is now clear that immune responses are induced to antigens in the brain, including those expressed by cerebral malignancies.

Outcome and patterns of failure in testicular lymphoma: a multicenter Rare Cancer Network study.

Purpose: To assess the outcome and patterns of failure in patients with testicular lymphoma treated by chemotherapy (CT) and/or radiation therapy (RT).

Methods And Materials: Data from a series of 36 adult patients with Ann Arbor Stage I (n = 21), II (n = 9), III (n = 3), or IV (n = 3) primary testicular lymphoma, consecutively treated between 1980 and 1999, were collected in a retrospective multicenter study by the Rare Cancer Network. Median age was 64 years (range: 21-91 years).