Publications by authors named "Pierre Clavel"
Background: Uncontrolled gout can cause articular impairment but is also associated with a global and cardiovascular excess mortality, especially in dialysis population. Data documented within existing research is not conclusive regarding gout flares evolution during hemodialysis and their control by urate lowering therapy (ULT). Without clear guidelines concerning hemodialysis patients management with chronic gout, this study proposes to investigate whether gout flare incidence reduction could be observed on this population treated by urate lowering therapy versus patients without treatment.
View Article and Find Full Text PDFBackground And Purpose: MR imaging is the technique of choice for patients presenting with acute loss of visual acuity with no obvious ophthalmologic cause. The goal of our study was to compare orbits contrast-enhanced 2D coronal T1WI with a whole-brain contrast-enhanced 3D (WBCE-3D) TSE T1WI at 3T for the detection of optic nerve enhancement.
Materials And Methods: This institutional review board-approved retrospective single-center study included patients presenting with acute loss of vision who underwent 3T MR imaging from November 2014 to February 2020.
Article Synopsis
- * Researchers discovered that most ancient DNA is released within 60 minutes at 37°C, suggesting a quick pre-digestion process is beneficial.
- * This method, combined with DNA capture techniques, enabled the analysis of 12 ancient bacteria from France related to pandemics in the 17th and 18th centuries.
Article Synopsis
- Scientists study old animal bones to learn how people took care of animals a long time ago, but it’s hard because the bones are often broken and there aren’t clear signs of age.
- *Using a special method called DNA methylation clocks, researchers can figure out how old some ancient animals were when they died.
- *They also looked at DNA to understand if horses were castrated in the past, which helps reveal more about how people managed animals and their lives a long time ago.
Article Synopsis
- Donkeys played a crucial role in human history as reliable transport animals, especially in tough terrains, yet their significance is not thoroughly researched.
- A study analyzed the genomes of 207 modern and 31 ancient donkeys, revealing that they were domesticated in Africa around 5000 BCE, with subsequent expansions across Africa and Eurasia.
- The research discovered a new genetic lineage from the Levant around 200 BCE, which contributed to donkey ancestry in Asia, highlighting the historical importance of donkeys in economies, particularly during the Roman era when mules were vital.
Article Synopsis
- Ancient DNA from subfossil specimens offers a way to retrieve genetic information, but environmental microbes often dominate these samples, requiring special techniques for accurate data collection.
- The study found that treating ancient DNA with a USER enzymatic mix before library construction can actually lower the effectiveness of data capture and introduce biases in the results.
- Specifically, they observed that this treatment led to uneven recovery of genetic material from different species (like horses and donkeys) in mule hybrids, suggesting that while USER-treatment may enhance some aspects of DNA quality, it complicates capture outcomes and can lead to unpredictable biases in genetic data.
Backround And Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.
Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.
Objective: To assess the cumulative incidence of restenosis and stroke after stenting for cervical carotid artery stenosis.
Methods: We reviewed PubMed, ScienceDirect, and Scopus and included all studies reporting restenosis after stenting. The cumulative incidence of restenosis at 6 and 12 months was calculated.
Background: Flow-diverter stent (FDS) deployment can cause morphological and hemodynamic changes in the carotid siphon (CS), influencing the occlusion rate of aneurysms in this location.
Objective: To evaluate morphological changes to the CS after FDS deployment and their relationship with the rate of occlusion of intracranial aneurysms.
Methods: A cohort of 183 patients with CS aneurysms were treated by deployment of Pipeline® FDS (Medtronic Inc, Dublin, Ireland).
Angiotensin I-converting enzyme inhibitors (ACEi), which are used to treat common cardiovascular diseases, are associated with a potentially life-threatening adverse reaction known as angioedema (AE-ACEi). We have previously documented a significant association between AE-ACEi and low plasma aminopeptidase P (APP) activity. With eight large pedigrees, we hereby demonstrate that this quantitative trait is partially regulated by genetic factors.
View Article and Find Full Text PDFThe A3243G mutation of the mitochondrial tRNA(Leu) gene has been recently reported in rare patients with focal and segmental glomerulosclerosis (FSGS). However, the full spectrum of systemic and kidney manifestations in adults presenting with this mutation remains poorly defined. Assessment of renal and nonrenal manifestations was performed in nine patients with A3243G mutation and prominent kidney disease diagnosed in adulthood.
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