Publications by authors named "Pierre Bareiss"
Background: The value of prehospital initiation of glycoprotein IIb/IIIa inhibitors remains a controversial issue. We sought to investigate whether in-ambulance initiation of abciximab in patients with ST-segment elevation myocardial infarction (STEMI) improves ST-segment elevation resolution (STR) after primary percutaneous coronary intervention (PCI).
Methods And Results: MISTRAL (Myocardial Infarction with ST-elevation Treated by Primary Percutaneous Intervention Facilitated by Early Reopro Administration in Alsace) is a prospective, randomized, double-blind study.
Article Synopsis
- This study aimed to investigate if low platelet response to clopidogrel, measured by a specific test, can predict cardiovascular events in patients undergoing percutaneous coronary intervention (PCI).
- The research involved 461 patients, classifying them based on their platelet reactivity index (PRI) to identify low responders and responders to clopidogrel, with a follow-up period averaging around 9 months.
- Results showed that patients with low response to clopidogrel had higher rates of cardiac mortality and stent thrombosis, indicating that lower platelet reactivity is a significant predictor of cardiovascular death in this high-risk group.
Atherothrombosis--defined as atherosclerotic lesion disruption with superimposed thrombus formation--is a leading cause of death in patients with diabetes mellitus. Platelets play a pivotal role in atherothrombosis and platelets of diabetic patients are hyperreactive. Numerous studies have investigated the usefulness of antiplatelet therapy for primary and secondary prevention of atherothrombotic events in diabetic patients.
View Article and Find Full Text PDFBackground: To gain more insight into the involvement of inflammatory response and neurohumoral activation in Takotsubo cardiomyopathy (TTC), we investigated C-reactive protein (CRP), leukocytes, plasma catecholamines levels, iodine 123 meta-iodobenzylguanidine (123I-mIBG) myocardial uptake, myocardial perfusion (thallium 201 [201Tl] or technetium [Tc] 99m-tetrofosmin myocardial single photon emission computed tomography [SPECT]), and metabolism (fluorine 18-fluorodeoxyglucose positron emission tomography).
Methods And Results: Inflammatory status and brain natriuretic peptide (BNP) levels in 17 patients with TTC were compared with 14 age-matched patients. In TTC, elevated levels of CRP were evidenced on admission, reaching a peak in the following days (P < .
Article Synopsis
- The study aimed to evaluate the usefulness of circulating Sta-Liatest D-Di levels in diagnosing classic acute aortic dissection (AAD) versus aortic intramural hematoma (AIH), which is a variant of AAD without a false lumen.
- The research involved 94 patients with AAD and d-dimer measurements, revealing that those with AIH had significantly lower d-dimer levels compared to those with classic AAD.
- The findings suggest that d-dimer testing may not be reliable for detecting AIH, as it can yield negative results in some cases, highlighting the need for careful interpretation in acute aortic syndrome patients.*
Article Synopsis
- The study examines the role of procoagulant microparticles (MPs) and their origins in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty.
- Researchers analyzed samples from 12 patients, comparing MPs in the occluded coronary artery before and after blood flow restoration, as well as in peripheral blood.
- Findings revealed significantly higher levels of specific types of MPs in the blocked artery, with restoration of blood flow reducing these levels, suggesting MPs contribute to coronary atherothrombosis during myocardial infarction.
Background: Circulating procoagulant microparticles are reliable markers of vascular damage. The microparticle phenotypes provide additional information reflecting the nature of cell injury. This study assessed procoagulant microparticle levels and phenotypes in the diagnosis of acute allograft rejection after heart transplantation.
View Article and Find Full Text PDFObjective: We sought to determine whether assessing D-Dimer might be helpful for the management of acute aortic dissection (AAD).
Design: Single-center retrospective case-control study.
Setting: University Hospital of Strasbourg France.