Publications by authors named "Pierre Allaume"

Mycosis fungoides (MF) and Sezary syndrome (SS) are common entities among primary cutaneous lymphomas. Large cell transformation is challenging for diagnosis and therapy. Molecular mechanisms by which these lymphomas undergo this transformation are poorly defined.

View Article and Find Full Text PDF
Article Synopsis
  • Iron is crucial for cell and overall body function, and Perls staining helps identify iron deposits in tissues.
  • Hepatic siderosis can be classified into three types: parenchymal, mesenchymal, or mixed, aiding in understanding its causes.
  • HFE1 hemochromatosis, the most prevalent form of siderosis, is diagnosed through genetic testing, and the presence of hepatic siderosis might indicate its occurrence, despite variability in expression and incomplete penetrance.
View Article and Find Full Text PDF

Langerhans cell histiocytosis (LCH) is a disease whose physiopathology remains unclear, involving both inflammatory processes and clonal proliferation. It is observable at any given age, although about ten times more frequent in children than adults. Hepatic involvement is not rare, mostly part of a systemic disease, and linked to a poor prognosis.

View Article and Find Full Text PDF

Mismatch repair deficiency (d-MMR)/microsatellite instability (MSI), , and mutational status are crucial for treating advanced colorectal cancer patients. Traditional methods like immunohistochemistry or polymerase chain reaction (PCR) can be challenged by artificial intelligence (AI) based on whole slide images (WSI) to predict tumor status. In this systematic review, we evaluated the role of AI in predicting MSI status, , and mutations in colorectal cancer.

View Article and Find Full Text PDF

Deep learning (DL), often called artificial intelligence (AI), has been increasingly used in Pathology thanks to the use of scanners to digitize slides which allow us to visualize them on monitors and process them with AI algorithms. Many articles have focused on DL applied to prostate cancer (PCa). This systematic review explains the DL applications and their performances for PCa in digital pathology.

View Article and Find Full Text PDF

To elucidate the spectrum of metastatic solid tumors to the testis and their clinicopathologic features. The databases and files of 26 pathology departments from 9 countries on 3 continents were surveyed to identify metastatic solid tumors to the testis and to characterize their clinicopathologic features in detail. We compiled a series of 157 cases of metastatic solid tumors that secondarily involved the testis.

View Article and Find Full Text PDF

Background: Artificial Intelligence (AI)-based Deep Neural Networks (DNNs) can handle a wide range of applications in image analysis, ranging from automated segmentation to diagnostic and prediction. As such, they have revolutionized healthcare, including in the liver pathology field.

Objective: The present study aims to provide a systematic review of applications and performances provided by DNN algorithms in liver pathology throughout the Pubmed and Embase databases up to December 2022, for tumoral, metabolic and inflammatory fields.

View Article and Find Full Text PDF
Article Synopsis
  • * A total of 98 cases of secondary testis tumors were identified, with prostate cancer being the most common primary source (38 cases), followed by colorectal and gastric cancers, with a median patient age of 66.5 years.
  • * The study highlights diagnostic challenges and proposes assessment strategies, discussing potential pathways for how cancer spreads from the original site to the testis, exemplified by the case studies presented.
View Article and Find Full Text PDF

Fumarate hydratase deficient renal cell carcinoma (FH-RCC) is a rare malignant neoplasia caused by constitutive or somatic mutations in the FH gene whose diagnosis is primordial, requiring genetic counselling. Because of histological heterogeneity, such tumors have been in the past misclassified as "type 2 papillary carcinoma", "tubulo-cystic renal cell carcinoma" or "high grade papillary carcinoma". We report here a case of FH deficient renal cell carcinoma (FH-RCC) in a 69years old patient.

View Article and Find Full Text PDF