Publications by authors named "Piero Ruscitti"
Article Synopsis
- The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
- A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
- Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
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Article Synopsis
Early psoriatic arthritis: clinical and therapeutic challenges.
Expert Opin Investig Drugs
September 2024
Article Synopsis
- * The review discusses diagnostic challenges, the disease's biology, and the benefits of early intervention on patient outcomes.
- * Experts suggest enhancing recognition of early inflammatory signs, improving screening for high-risk patients, and increasing awareness among doctors and patients to better manage PsA.
Article Synopsis
- The study investigates the relationship between Familial Mediterranean fever (FMF), a severe inflammatory condition, and the risk of cancer development compared to other diseases like fibromyalgia, Still's disease, and Behçet's disease.
- Results show that FMF patients have a significantly lower risk for malignancies compared to fibromyalgia patients, with a risk ratio (RR) of 0.26; however, this risk is less clear when comparing with the other conditions.
- Factors influencing cancer risk in FMF patients include age at onset and diagnosis, frequency of disease attacks, and treatment with specific biotechnological agents.
Article Synopsis
- The study aimed to evaluate the short-term effectiveness of guselkumab in treating patients with psoriatic arthritis (PsA) who showed signs of axial involvement over a period of 4 months.
- A total of 67 patients were monitored, and significant improvements were noted in various health assessments (BASDAI, ASDAS, DAPSA), with over half achieving a BASDAI score of 4 or lower.
- MRI assessments indicated that most patients also showed improvement in sacroiliac joint lesions, and while minor side effects were reported, no serious adverse reactions were noted, suggesting guselkumab's potential clinical use in these patients.
Article Synopsis
- - VEXAS syndrome is a new autoinflammatory disease that often affects various organs, with noticeable inflammatory issues in the eyes and orbits.
- - In a study of 59 VEXAS patients, 45.8% exhibited orbital/ocular problems, with periorbital edema and episcleritis being the most common conditions observed.
- - There is a significant link between relapsing polychondritis and eye involvement in VEXAS, and patients with eye issues showed higher mortality rates, indicating the need for closer monitoring by healthcare providers.
Article Synopsis
- This study evaluated the effectiveness of a systemic score in predicting severe outcomes in patients with Still disease, including the risk of mortality and severe complications like macrophage activation syndrome.
- Involving 597 patients, the study found that a higher systemic score significantly correlated with life-threatening outcomes, with scores of 7 or above indicating a greater risk.
- Key components that were most predictive of severe outcomes included liver and lung involvement, emphasizing the importance of these factors in managing Still disease.
Article Synopsis
- The objective of the study was to systematically review the effectiveness and safety of pharmacological treatments for adult-onset Still disease (AOSD) by analyzing data from various sources over an 11-year period.
- A total of 44 studies were examined, highlighting treatments such as NSAIDs, corticosteroids, and biologic DMARDs, with tocilizumab (TCZ), anakinra (ANK), and canakinumab (CNK) showing significant remission rates and corticosteroid (CS) discontinuation.
- While evidence supports the use of TCZ, ANK, and CNK for AOSD, findings indicate variability in treatment effectiveness and uncertainty about the comparative effectiveness of these therapies.
The latest advances in the use of biological DMARDs to treat Still's disease.
Expert Opin Biol Ther
February 2024
Article Synopsis
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- Many biological drug patents have expired, leading to the development of biosimilar agents (BIOs), but their use in children raises concerns, prompting a study on their efficacy and safety for treating pediatric non-infectious uveitis (NIU).
- Data collected from pediatric patients treated with TNF inhibitors BIOs showed a significant decrease in flare-ups and ocular complications, as well as a reduction in the need for glucocorticoids during treatment.
- The study included 47 patients, demonstrating strong treatment retention rates and maintaining visual acuity throughout the therapy, while only recording a few minor adverse events.