Publications by authors named "Piero Reynolds"
A woman in her 20s presented with chest pain, dyspnoea, arthralgia, muscle weakness and skin discolouration. She was diagnosed with dermatomyositis. During her admission, she developed pleuritic chest pain and shortness of breath accompanied by a significant troponin I rise.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of tocilizumab compared to rituximab for patients with rheumatoid arthritis who do not respond well to anti-TNF treatments, particularly focusing on patients with low or absent CD20 B cells in their joints.
- Conducted as a 48-week randomized controlled trial across multiple European countries, the research involved 19 centers and included patients over 18 who met certain criteria for participating in the trial.
- Patients were categorized based on their synovial biopsy results as B-cell poor or rich, and those classifications informed their treatment assignment to either rituximab or tocilizumab.
Background: Rheumatologists increasingly perform ultrasound (US) imaging to aid diagnosis and management decisions. There is a need to determine the role of US in facilitating early diagnosis of inflammatory arthritis. This study describes the impact of US use by rheumatologists on diagnosis and management of inflammatory arthritis in routine UK clinical practice.
View Article and Find Full Text PDFAcute pulmonary embolism (PE) is associated with a wide variation in patient outcome ranging from completely asymptomatic to cardiac failure and death. This presents a challenge to clinicians in ensuring the correct treatment for individual patients is given and that adverse events secondary to treatment complications are minimised. The evidence for those with massive PEs and non-massive PEs is clear for and against the use of thrombolysis, respectively.
View Article and Find Full Text PDFOsteoporosis commonly causes vertebral collapse fractures. We present a patient with multiple vertebral fractures in the context of severe osteoporosis, who, in the course of investigation for intractable spine and hip pain, was found to have an IgA myeloma. At 2 months post diagnosis, she was discharged home to continue outpatient chemotherapy.
View Article and Find Full Text PDFObjective: To describe the prevalence and clinical associations of abnormalities on electroencephalography (EEG) in patients with antiphospholipid syndrome (APS) and/or systemic lupus erythematosus (SLE) who have neuropsychiatric symptoms.
Methods: The study group comprised 57 patients (age View Article and Find Full Text PDF