Publications by authors named "Pierina Casanova"
Article Synopsis
- Antimicrobial responses are crucial for gut health, and the study focuses on how miR-511 affects TLR4 responses, leading to increased intestinal inflammation.
- Mice lacking miR-511 showed less severe colitis symptoms and lower inflammatory cytokine levels compared to normal mice when exposed to DSS, indicating a protective role against intestinal inflammation.
- The research also identified Wdfy1 as a target of miR-511, suggesting that diminished WDFY1 levels in miR-511-deficient macrophages contribute to reduced immune responses from TLR3 and TLR4.
Malaria remains one of the most serious health problems in developing countries. The causative agent of malaria, spp., have a complex life cycle involving multiple developmental stages as well as different morphological, biochemical and metabolic requirements.
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