Publications by authors named "Piergiuseppe Fiore"
Article Synopsis
- Extracellular matrix (ECM) alterations that cause increased matrix deposition and stiffening are key features of adenocarcinomas, known as desmoplasia.
- In our study of primary prostate cancer tissues from patients, we identified distinct structural changes in the ECM that disrupt normal glandular architecture.
- By creating prostate cancer tumoroids (PCTs) from these tissues and manipulating TGF-β signaling, we discovered its critical role in ECM remodeling, initiating epithelial-to-mesenchymal transition (EMT), and facilitating tumor progression and spread.
