Clinical Implementation of Knowledge-Based Automatic Plan Optimization for Helical Tomotherapy.

Purpose: To implement knowledge-based (KB) automatic planning for helical TomoTherapy (HTT). The focus of the first clinical implementation was the case of high-risk prostate cancer, including pelvic node irradiation.

Methods And Materials: One hundred two HTT clinical plans were selected to train a KB model using the RapidPlan tool incorporated in the Eclipse system (v13.