Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system's actual motor output - the activation of muscle fibers by motor neurons - typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups.
View Article and Find Full Text PDFNeurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system's actual motor output - the activation of muscle fibers by motor neurons - typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups.
View Article and Find Full Text PDFFunctional neuroimaging research in the non-human primate (NHP) has been advancing at a remarkable rate. The increase in available data establishes a need for robust analysis pipelines designed for NHP neuroimaging and accompanying template spaces to standardize the localization of neuroimaging results. Our group recently developed the NIMH Macaque Template (NMT), a high-resolution population average anatomical template and associated neuroimaging resources, providing researchers with a standard space for macaque neuroimaging .
View Article and Find Full Text PDFTwo new chemosensors, rhodamine B derivative bearing 3-formyl-6-nitrochromone ( ) and 3-formyl-6-methylchromone ( ) units were designed and synthesized using microwave irradiation for the selective detection of Cu in aqueous media. Copper triggers the formation of highly fluorescent ring-open spirolactam. The fluorescence intensity was remarkably increased upon the addition of Cu within a minute, while the other metal ions caused no significant effect.
View Article and Find Full Text PDFTwo new rhodamine derivative L and L bearing 2-methoxy-1-naphthaldehyde and 5-bromo-3-methoxy salicylaldehyde units were designed and synthesized using microwave-assisted organic synthesis and utilized towards sequential fluorescence detection of aluminum ion (Al ) and azide (N ) in aqueous acetonitrile solution. Aluminum ion (Al ) triggers the formation of highly fluorescent ring-open spirolactam. The fluorescence and colorimetric response of the L -Al and L -Al complexes were quenched by the addition of N , which extracting the Al from the complexes and turn-off the sensors, confirming that the recognition process is reversible.
View Article and Find Full Text PDFThe microwave synthesis of 12 rhodamine-derived imines is described. The present work involves condensation of rhodamine hydrazide with various aromatic aldehydes in ethanol under microwave irradiation. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction time, mild reaction condition and simple work-up procedure.
View Article and Find Full Text PDF