Publications by authors named "Piercarlo Sarzi-Puttini"
Article Synopsis
- - Fibromyalgia (FMS) is a chronic pain syndrome linked to broad systemic symptoms, and researchers explored its potential connection to mitochondrial dysfunction by studying blood cells from 50 FMS patients and 20 healthy individuals.
- - While no significant differences in mitochondrial respiration were found between the groups, FMS patients had a notably lower bioenergetic health index (BHI) indicating poorer mitochondrial function, particularly in those with more severe symptoms.
- - The study showed a moderate negative correlation between BHI and both fibromyalgia severity scores and widespread pain index, suggesting that mitochondrial impairment may play a role in musculoskeletal pain rather than affecting the central nervous system.
Article Synopsis
- The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
- A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
- Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
Article Synopsis
- Patients with Immune-Mediated Inflammatory Diseases (IMIDs) face a higher risk of cancer, although the reasons behind this link are still debated.
- The review discusses how factors like environmental influences, genetics, and chronic inflammation contribute to both IMIDs and cancer development, focusing on mechanisms such as an inflammatory microenvironment and abnormal cell communication.
- The authors emphasize the need for further research to address existing gaps in knowledge and improve patient care related to the connections between IMIDs and cancer.
Background: Geographic origin may represent a variable capable of influencing health status. This study aims to investigate the presence of differences of disease severity in Italian patients with fibromyalgia from different macro-regions.
Methods: This retrospective, cross-sectional study involved patients included in the Italian Fibromyalgia Registry.
Corrigendum: Evidence for a genetic contribution to the ossification of spinal ligaments in ossification of posterior longitudinal ligament and diffuse idiopathic skeletal hyperostosis: a narrative review.
Front Genet
August 2024
Article Synopsis
- The text discusses a correction to a previously published article indexed under the DOI 10.3389/fgene.2022.987867.* -
- The correction aims to address specific inaccuracies or errors found in the original study.* -
- This update is important for maintaining the integrity of the research and ensuring accurate scientific communication.*
Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus.
Autoimmun Rev
September 2024
Article Synopsis
Symptoms of fibromyalgia (FM) fluctuate and vary in severity. The current study aimed to evaluate the efficacy of palmitoylethanolamide (PEA) and acetyl-L-carnitine (ALC) in FM patients over a 24-month period and to investigate the mediating function of pain catastrophizing subdomains in unfavorable relationships with disease severity levels in patients with FM. Patients were evaluated at baseline, after 12 months, and after 24 months, using different patient-reported measures (FIQR, FASmod, PSD, and PCS) to distinguish different levels of FM disease severity.
View Article and Find Full Text PDFPurpose Of Review: Fibromyalgia Syndrome (FMS) is a complex chronic pain condition characterized by widespread musculoskeletal pain and numerous other debilitating symptoms. The purpose of this review is to provide a comprehensive overview, based on everyday clinical practice, of the drugs presently employed in the treatment of FMS.
Recent Findings: The treatment of FMS is based on a multimodal approach, with pharmacologic treatment being an essential pillar.
Pain is a significant issue in rheumatoid arthritis (RA) and psoriatic arthritis (PSA) and can have a negative impact on patients' quality of life. Despite optimal control of inflammatory disease, residual chronic pain remains a major unmet medical need in RA. Pain in RA can be secondary to inflammation but can also generate neuroendocrine responses that initiate neurogenic inflammation and enhance cytokine release, leading to persistent hyperalgesia.
View Article and Find Full Text PDFArticle Synopsis
- This review discusses how the immune system and nervous system interact in both acute and chronic pain, highlighting the complex bidirectional communication between immune cells and nerve fibers.
- Recent studies show that the immune system plays a crucial role in pain mechanisms, influencing pain sensations and responses, while small signaling molecules help modulate immune activity.
- The findings from this research can lead to new treatment strategies targeting the immune system, potentially improving pain management beyond traditional opioid therapies.
Article Synopsis
- The text evaluates how exercise can help manage fibromyalgia syndrome (FM) by addressing its multiple complications, including central sensitization and inflammation.
- It reviews the benefits of tailored exercise programs and highlights that the type, intensity, frequency, and duration of exercise should be personalized for each patient.
- Regular physical activity not only alleviates FM symptoms but also helps with stress, obesity, and the prevention of chronic diseases, ultimately improving patients' quality of life.
Article Synopsis
- Fibromyalgia (FM) is a complex condition with chronic pain, fatigue, sleep issues, and varying symptoms, necessitating a comprehensive approach that addresses psychological influences on patient responses.
- Environmental factors like climate, pollution, trauma, and diet significantly affect FM symptoms, highlighting the need for personalized treatment plans that incorporate dietary changes and stress management.
- There is a strong call for more research to understand how environmental, biological, and psychological factors interact in FM, aiming to improve individualized treatments and enhance patient care.
Pharmacotherapeutic advances in fibromyalgia: what's new on the horizon?
Expert Opin Pharmacother
June 2024
Introduction: This review delves into Fibromyalgia Syndrome (FMS), a chronic pain condition demanding thorough understanding for precise diagnosis and treatment. Yet, a definitive pharmacological solution for FMS remains elusive.
Areas Covered: In this article, we systematically analyze various pharmacotherapeutic prospects for FMS treatment, organized into sections based on the stage of drug development and approval.
Article Synopsis
- The study aimed to validate the Qualisex questionnaire for assessing sexual dysfunction in women with fibromyalgia (FM) and included 373 participants from a Fibromyalgia Clinic.
- Results showed that higher Qualisex scores correlated with factors like anxiety, depression, pain, fatigue, and relationship duration, indicating a negative impact of FM on sexual life.
- The findings suggest that the Qualisex questionnaire can effectively evaluate sexual disorders in FM patients and highlight the broader implications of FM on their quality of life.
Objectives: Central sensitivity (CS) is defined as an increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold inputs. CS has recently been linked to the psychological burden associated with chronic pain, such as fibromyalgia (FM). The primary objective of this study is to investigate the impact of specific psychological constructs on CS in patients with FM.
View Article and Find Full Text PDFFibromyalgia (FM) remains a condition with a pathogenesis that is not completely understood, affecting a significant portion of the global population. This article summarises the main advances in FM during the last year. Even in 2023, research on FM was notably active.
View Article and Find Full Text PDFFibromyalgia is a complex and often misunderstood chronic pain disorder. It is characterized by widespread musculoskeletal pain, fatigue, and heightened sensitivity, and has evolved in diagnostic criteria and understanding over the years. Initially met with skepticism, fibromyalgia is now recognized as a global health concern affecting millions of people, with a prevalence transcending demographic boundaries.
View Article and Find Full Text PDFArticle Synopsis
- Pain is a big problem for people with rheumatoid arthritis (RA) and can make their lives harder, even if their inflammation is under control.
- Chronic pain in RA is not just due to inflammation but also involves other body mechanisms, like neurogenic inflammation, which can lead to increased sensitivity to pain.
- Some treatments, like JAK inhibitors, are showing promise in helping to reduce this persistent pain, even if they don’t directly fight inflammation.
Introduction: The Feldenkrais Method® is a form of awareness through movement (ATM) aimed at improving spatial and kinesthetic awareness through verbally guided movements, in order to learn more effective actions.
Method: The present study, a proof-of-concept, observational, non-controlled prospective study, aims at exploring the effectiveness of ATM for fibromyalgia syndrome (FM), measuring the effect by means of multi-dimensional questionnaires, administered at baseline and after 4 months of ATM activity.
Results: One hundred twenty-eight FM patients (mean age 54 years old, 2% males) participated in the study.
Article Synopsis
- Fibromyalgia is a tough condition to diagnose and treat because it can cause many different symptoms and other health issues at the same time.
- *People with fibromyalgia can also have other problems like migraines, stomach issues, and extra pain, which makes it all more complicated.
- *There are medicines and therapies that can help, but it's important to find the treatment that works best for each person, and some options like certain exercises and therapy can be really helpful too.
Objectives: We aimed to investigate the effectiveness of tumour necrosis factor inhibitors (TNFi), anti-interleukin-17 or interleukin-12/23 monoclonal antibodies (anti-IL) on comorbidities in a cohort of patients with spondyloarthritis (SpA), using an average treatment effect (ATE) analysis.
Methods: SpA patients from the multicentre Italian GISEA Registry were divided into groups according to pharmacological exposure: no treatment (G0), TNFi (G1) and non-responders to TNFi switched to anti-IL (G2). In each group, we recorded the prevalence and incidence of infectious, cardiopulmonary, endocrinological, gastrointestinal, oncologic, renal and neurologic comorbidities.
Article Synopsis
- * Current theories suggest that FM may develop due to a combination of genetic factors, stress, inflammation, and cognitive-emotional influences, but no single explanation has been definitively established.
- * The article presents a debate between two experts on whether FM should be classified as an autoimmune disease, examining scientific evidence to explore differing viewpoints on its pathophysiology.