Regular physical activity prevents development of left ventricular hypertrophy in hypertension.

Aims: The longitudinal relationship between aerobic exercise and left ventricular (LV) mass in hypertension is not well known. We did a prospective study to investigate the long-term effect of regular physical activity on development of LV hypertrophy (LVH) in a cohort of young subjects screened for Stage 1 hypertension.

Methods And Results: We assessed 454 subjects whose physical activity status was consistent during the follow-up.

alpha-Adducin Gly460Trp polymorphism, left ventricular mass and plasma renin activity.

Objective: Left ventricular hypertrophy (LVH) is associated with an increased risk for cardiovascular morbidity and mortality. Epidemiological studies suggest that LVH may be influenced by genetic factors. However, the evidence associating individual genes with left ventricular (LV) mass is inconsistent and contradictory.