Publications by authors named "Pier Edoardo Rovatti"
Article Synopsis
- - The study investigates how the HLA class I genotype influences the size of the HIV viral reservoir in individuals on antiretroviral therapy (ART), highlighting the significant roles of HLA-B and -C genes in this process.
- - Using advanced bioinformatic tools, the researchers assessed the relationship between HLA alleles and HIV antigen presentation, finding that certain HLA types, like HLA-B*57:01 and HLA-B*58:01, may enhance immune responses against HIV.
- - The research suggests a potential interaction between specific HLA-peptide complexes and factors like the CCR5 ∆32 mutation in regulating HIV replication and controlling the size of the viral reservoir, proposing a multifaceted approach to understanding HIV management
Over the last decade, the development of multiple strategies to allow the safe transfer from the donor to the patient of high numbers of partially HLA-incompatible T cells has dramatically reduced the toxicities of haploidentical hematopoietic cell transplantation (haplo-HCT), but this was not accompanied by a similar positive impact on the incidence of post-transplantation relapse. In the present review, we will elaborate on how the unique interplay between HLA-mismatched immune system and malignancy that characterizes haplo-HCT may impact relapse biology, shaping the selection of disease variants that are resistant to the "graft-vs.-leukemia" effect.
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