Publications by authors named "Pier C Parodi"

Background: Evidence-based medicine and patient-reported outcome measures (PROMs) are helpful tools in the wound care field, but few studies correlating quality of life (QoL) changes with objective changes exist.

Objective: To investigate the QoL changes following the shift from primary dressings alone to elastic compression bandages in patients with a new diagnosis of vascular skin ulcer, and to evaluate a possible correlation between objective and subjective changes.

Materials And Methods: This study included 122 patients with a new diagnosis of vascular skin ulcer, who had previously used only primary dressings alone.

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Corneal injuries, which make up 3% of emergency room visits, can vary from small scratches to exposure or trauma-related damage that might be fatal to vision. Mechanical trauma, diseases of the eyelids, neurotrophic abnormalities, and chemical burns are common causes. A thorough examination is necessary for an accurate diagnosis and treatment plan.

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Article Synopsis
  • Weight loss patients often have significant abdominal skin laxity due to rapid weight loss and bariatric surgery, prompting the development of new body contouring techniques.
  • This study evaluated the effectiveness of helium plasma radiofrequency (HPRF) technology for tightening skin after lipoabdominoplasty in 100 patients, focusing on safety, satisfaction, and outcomes.
  • Findings showed high patient satisfaction (88% rated 5/5 on the Likert scale) and minimal complications, demonstrating that HPRF-assisted lipoabdominoplasty can enhance body contouring with lower risk of scarring and complications.
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Background: Infections associated with implant-based breast reconstructive surgery are challenging for both patients and surgeons, often implying high recurrence rate, long treatments (both medical and surgical management), multiple invasive procedures, and delay of the end-result and, in some cases, even reconstruction failure. Early diagnosis is crucial but not always easy to achieve. Various treatment options are available and have been described in literature, with no clear winning strategy.

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: Surgeons have long been aware of Murphy's Law: "If anything can go wrong, it will". When applied to surgery, Murphy's Law suggests that if there is a way that an operation can be set up incorrectly then someday, somewhere, it will be set up incorrectly. This paper focuses on complications in medical doctor (MD) and VIPs during aesthetic surgery.

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Workers involved in the decommissioning and removal of radioactive material from nuclear power plants can come into contact with tritiated dust from stainless steel. This study aimed to investigate metal penetration and permeation after skin contamination with these particles. Static diffusion Franz cells were used with intact, damaged, or broken human skin.

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Targeted drug delivery has emerged as a transformative approach in the treatment of periorbital skin malignancies, offering the potential for enhanced efficacy and reduced side effects compared to traditional therapies. This review provides a comprehensive overview of targeted therapies in the context of periorbital malignancies, including basal cell carcinoma, squamous cell carcinoma, sebaceous gland carcinoma, and Merkel cell carcinoma. It explores the mechanisms of action for various targeted therapies, such as monoclonal antibodies, small molecule inhibitors, and immunotherapies, and their applications in treating these malignancies.

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Background: Over the past two decades, liposuction techniques have significantly evolved, moving from basic fat removal to sophisticated methods aimed at improving safety, efficiency, and cosmetic outcomes. This study evaluates the efficacy and safety of a combined approach using ultrasound-assisted liposuction (UAL) and helium plasma radiofrequency (HPRF) technology to enhance skin tightening without the need for extensive surgical interventions.

Methods: We conducted a retrospective analysis of 639 patients who underwent the combined UAL and HPRF liposuction technique.

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Article Synopsis
  • - Floppy Eyelid Syndrome (FES) is a common but often overlooked eye condition that causes loose upper eyelids, resulting in eye irritation and redness.
  • - The review explores the causes of FES, including genetic factors and links to other health issues like obesity and sleep apnea, as well as detailing diagnostic methods necessary for effective treatment.
  • - Treatment options for FES vary from basic medical care to surgical procedures, requiring a team-based approach to improve the quality of life for those affected by this condition.
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Preadipocytes are formed during the 14th and 16th weeks of gestation. White adipose tissue, in particular, is generated in specific areas and thereby assembles after birth, rapidly increasing following the propagation of adipoblasts, which are considered the preadipocyte cell precursors. The second trimester of gestation is a fundamental phase of adipogenesis, and in the third trimester, adipocytes, albeit small may be present within the main deposition areas.

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Breast reconstructive surgery has evolved significantly over the years. One of the recent advancements is the use of prepectoral implants in combination with synthetic and biological material as a natural and effective coverage. To date, there is little published data on breast reconstruction using acellular bovine pericardium matrix and most concern submuscular breast reconstruction.

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Article Synopsis
  • - Whole-eye transplantation presents a revolutionary potential for treating irreversible blindness, but significant challenges remain, particularly in preserving donor eye health and achieving successful optic nerve regeneration.
  • - Key hurdles include developing effective surgical techniques to maintain retinal integrity, enhancing neurotrophic support for nerve healing, and addressing the unique immune reactions associated with eye tissue to ensure graft acceptance.
  • - Ongoing interdisciplinary research is vital, focusing on innovations like biomaterials and stem cell therapies, while ethical and legal standards are essential to guide this emerging field towards successfully restoring vision and improving patients' lives.
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Background: As one of the most common aesthetic surgical procedures carried out today, blepharoplasty should be in the repertoire of every plastic surgeon. The term blepharoplasty encompasses a wide range of techniques and options that must be tailored to the specific defect and patient one has to treat. A sound knowledge of the upper and lower eyelids' anatomy is essential for proper surgical execution.

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The aging of the periocular region has always aroused great interest. A fresh, young, and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this result. In particular, the change in the concept of a young look, considered then "full", led to the increasing use of surgical (fat grafting) or medical (hyaluronic acid) filling techniques.

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Gynecomastia is defined as a benign condition of the male caused by tissue overgrowth (Blau and Hazani in Plast Reconstruct Surg 135(2): 425-432, 2015). Its incidence ranges widely in the world population, ranging from 32 to 65% (Innocenti et al. in Ann Plast Surg 78(5):492-496, 2017).

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Background: During the sexual maturation, gluteal femoral adipose tissue is subjected to numerous modifications, not observable in other regions, in particular in women and less in men. Other authors described this region, but they used imaging techniques having lower resolution, than MRI proposed in this study. High resolution imaging techniques might provide important and more detailed information about the anatomy of gluteal femoral region.

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This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enhancement, demands advanced solutions for tissue restoration, functional and aesthetic refinement, and aging. Investigating immunomodulatory, regenerative, and healing capacities of MSCs, this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside, addressing common unmet needs in the field of reconstructive and regenerative surgery.

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Plastic surgeons have used the reconstructive ladder for many decades as a standard directory for complex trauma reconstruction with the goal of repairing body structures and restoring functionality. This consists of different surgical maneuvers, such as secondary intention and direct tissue closure, as well as more complex methods such as local tissue transfer and free flap. The reconstructive ladder represents widely known options achievable for tissue reconstruction and wound closure that puts at the bottom rung the simplest methods of reconstruction and strengthens the complexity by moving upward.

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