Family studies and HLA typing in ankylosing spondylitis and sacroiliitis.

The families of 21 ankylosing spondylitis (AS) and 16 sacroiliitis (SI) patients were investigated and typed for HLA markers. The association of HLA B27 with AS was confirmed, but no strong evidence for the same or other HLA markers being associated with SI was found. Inheritance patterns in families were analyzed according to the multifactorial and monofactorial models.

Immunoglobulin allotypes in Sardinia.

1218 individuals from Sardinia island (Italy) were tested for Gm and Km markers; 10 were not tested for Gm and only 401 were typed for Am markers. The peculiar genetic makeup of the Sardinian population is confirmed by their Gm allotypes. Their differences from those found in a control population of continental Italy (Ferrara), suggest ancient contacts with the Middle East and Africa.

[Frequency of goiter and urinary iodine in the Peidmont school children. Data on iodine contents in some local food].

The frequency of thyroid alterations was examined and dietary iodine intake was assessed via urinary iodine in 6-15 yr-old schoolchildren from 145 towns in Piedmont and the Aosta Valley. Local food iodine values were also determined in 56 towns. Alteration frequency and daily urinary elimination of iodine were inversely proportional, even within individual school populations.

An inclusion analysis for studying HL-A specificities.

INCLAN (Inclusion analysis) is a computer program which provides a systematic search for the subtypic variants of a given serological specificity. This routine was found especially useful for the HL-A serology whose complexity often needs automatic displays. A detailed description of its structure is presented in this note.

On the heterogeneity of linkage estimations between LA and four loci of the HL-A system,

Three cases of crossing over between the LA and FOUR loci of HL-A system are presented in this note. Recombination fractions between those two loci are also calculated from familial data kindly provided by other European laboratories. It is suggested that differences found in maternal and paternal recombination frequency are due to the heterogeneity of estimates of each laboratory.