Actin-related protein 2/3 complex subunit 2-enriched extracellular vesicles drive liver cancer metastasis.

Background: Extracellular vesicles (EVs) play pivotal roles in tumor growth, cancer metastasis and angiogenesis. Here, we aimed to identify proteins that contribute to the functionality of EVs derived from metastatic hepatocellular carcinoma (HCC) cells.

Methods: Proteins of EVs derived from metastatic HCC cells and normal liver cells were analyzed by mass spectrometry.