Skin microvascular function in patients with type 1 diabetes: An observational study from the onset of diabetes.

Background: The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start.

Material And Methods: Seventeen adult patients with type 1 diabetes participated.

Atorvastatin has antithrombotic effects in patients with type 1 diabetes and dyslipidemia.

Introduction: Diabetes is a prothrombotic state involving a more thrombogenic fibrin network. In the present study we investigated the effects of lipid-lowering therapy with atorvastatin on fibrin network structure and platelet-derived microparticles in patients with type 1 diabetes and dyslipidemia.

Materials And Methods: Twenty patients were treated with atorvastatin (80 mg daily) or placebo during 2 months in a randomized, double-blind, cross-over study.