Publications by authors named "Pia Madeleine Leipe"
Antiretroviral therapy (ART) transformed HIV from a life-threatening disease to a chronic condition. However, eliminating the virus remains an elusive therapy goal. For several decades, Friend virus (FV) infection serves as a murine model to study retrovirus immunity.
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- Human cytomegalovirus (CMV) disrupts the antiviral response by depleting the STAT2 transcription factor, which is essential for signaling against viral infections.
- This depletion is mediated by the viral protein E27, which triggers the degradation of STAT2 using cellular mechanisms that involve ubiquitin ligase complexes.
- Structural analyses reveal how E27 mimics host proteins to effectively recruit and degrade STAT2, highlighting a conserved strategy for immune evasion in both rat and mouse models of CMV infection.