Publications by authors named "Pia Korbel"
Ependymomas (EPN) are central nervous system tumors comprising both aggressive and more benign molecular subtypes. However, therapy of the high-risk subtypes posterior fossa group A (PF-A) and supratentorial RELA-fusion positive (ST-RELA) is limited to gross total resection and radiotherapy, as effective systemic treatment concepts are still lacking. We have recently described fibroblast growth factor receptors 1 and 3 (FGFR1/FGFR3) as oncogenic drivers of EPN.
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- - Ependymomas are a type of brain tumor in children that often reoccur even after complete surgical removal, and recent studies have identified different molecular subgroups of these tumors, though their aggressive behavior is not fully understood.
- - This study investigated the role of telomerase reactivation, a common cancer mechanism for avoiding aging, in specific pediatric ependymoma subgroups by analyzing various molecular markers like telomerase activity and genetic variations in a patient cohort.
- - Results showed that certain subgroups (particularly PF-EPN-A and ST-EPN-RELA) experienced significant telomerase activation linked to poorer survival rates, highlighting the importance of telomerase in disease progression and revealing potential molecular pathways influencing this process.