Aurora-A expression, hormone receptor status and clinical outcome in hormone related cancers.

Aims: We investigated the correlation between protein expression of Aurora-A with hormone receptor expression and clinicopathological parameters in ovarian, breast and prostate cancer.

Methods: Subcellular expression of Aurora-A, and androgen receptor (AR), oestrogen receptor (ER) and progesterone receptor (PR) expression, were examined by immunohistochemistry in human tissue microarrays of the three cancer types and by Western blot in cancer cell lines and selected patient tissues.

Results: Subgroups of all three cancer types exhibited both nuclear and cytoplasmic expression of Aurora-A.