Overexpression of Contactin 1 promotes growth, migration and invasion in Hs578T breast cancer cells.

Background: Contactin1 (CNTN1) has been shown to play an important role in the invasion and metastasis of several tumors; however, the role of CNTN1 in breast cancer has not been fully studied. The purpose of this study is to investigate the role of CNTN1 in regulating tumor growth, migration and invasion in breast cancer.

Results: To investigate its function, CNTN1 was expressed in Hs578T cells.

[Upregulation of survivin in non-small cell lung cancer and its clinicopathological correlation with p53 and Bcl-2].

Aim: To retrospectively analyze the clinicopathological data of 87 non-small cell lung cancer (NSCLC) specimens and explore the clinicopathological correlation of survivin with p53 and Bcl-2 and the applicability of combined detection for NSCLC prognosis.

Methods: Survivin, p53 and bcl-2 expression levels were examined in 87 NSCLC specimens using streptavidin-peroxidase (SP) immunohistochemistry. The correlation with NSCLC was analyzed with Spearman rank correlation test.