Publications by authors named "Phyu Hninn Nyein"
Background: Previous studies suggest that active selection limits the number of HIV-1 variants acquired by a newly infected individual from the diverse variants circulating in the transmitting partner. We compared HIV-1 envelopes from 9 newly infected subjects and their linked transmitting partner to explore potential mechanisms for selection.
Results: Recipient virus envelopes had significant genotypic differences compared to those present in the transmitting partner.
Article Synopsis
- A study was conducted in Rakai, Uganda, to analyze the diversity of HIV-1 during sexual transmission, focusing on how genetic bottlenecks affect viral diversity over time.
- Researchers examined HIV-1 sequences from individuals in HIV-discordant relationships and found that the viral diversity within infected individuals (intrahost) was significantly higher than the diversity between different individuals (interhost).
- The results indicated that most newly infected individuals carried viral strains that were more similar to their donor partner's earlier strains, suggesting that sexual transmission tends to favor the transmission of older, ancestral viral strains over newer ones.
As HIV-1 evolves over the course of infection, resistance against antiretrovirals may arise in the absence of drug pressure, especially against receptor and fusion blockers because of the extensive changes observed in the envelope glycoprotein. Here we show that viruses from the chronic phase of disease are significantly less sensitive to CCR5 receptor and fusion blockers compared to early infection variants. Differences in susceptibility to CCR5 antagonists were observed in spite of no demonstrable CXCR4 receptor utilization.
View Article and Find Full Text PDF