Publications by authors named "Phuong-Nhung Vu"
Background: Antioxidant genes, such as superoxide dismutase (SOD), catalase (CAT), and nitric oxide synthase (NOS), play critical roles in spermatogenesis and sperm functions. Polymorphisms of antioxidant genes have been shown to be strongly associated with sperm quality which affects male fertility.
Methods: To investigate the association of antioxidant gene polymorphisms to male infertility in Vietnamese men, in this case-control study, using Sanger sequencing, we genotyped four variants SOD1:7958G>A, SOD2:c.
Article Synopsis
- Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder linked to mutations in certain genes that affect the TGF-β signaling pathway, leading to vascular malformations.
- The study aimed to test whether increasing levels of the proteins ALK1 or ENG could help treat HHT by preventing the development of arteriovenous malformations (AVMs) in mouse models.
- Findings showed that overexpressing ALK1 successfully suppressed AVM formation, while ENG overexpression did not show similar benefits, suggesting that enhancing ALK1 could be a promising therapeutic strategy for HHT. *
Background: TMEM100 is identified as a downstream gene of bone morphogenetic protein 9 (BMP9) signaling via activin receptor-like kinase 1 (ALK1), which is known to participate in lymphangiogenesis as well as angiogenesis. TMEM100 has been shown to be important for blood vessel formation and maintenance, but its role in the development of lymphatic vasculature remains unknown. The objective is to investigate the role of TMEM100 in development of the lymphatic system.
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