Publications by authors named "Phuong-Khanh Nguyen"

The brain is consisted of diverse neurons arising from a limited number of neural stem cells. neural stem cells called neuroblasts (NBs) produces specific neural lineages of various lineage sizes depending on their location in the brain. In the visual processing centre - the optic lobes (OLs), medulla NBs derived from the neuroepithelium (NE) give rise to neurons and glia cells of the medulla cortex.

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Between 2010 and 2011, stakeholders implemented a multi-faceted community-based intervention in response to the escalating issue of uncontrolled hypertension in Hung Yen province, Vietnam. This initiative integrated expanded community health worker services, home blood pressure self-monitoring, and a unique "storytelling intervention" into routine clinical care. From the limited societal perspective, our study evaluates the cost-effectiveness of this intervention using a Markov model with a one-year cycle over a lifetime horizon.

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Article Synopsis
  • - The study assesses the cost-effectiveness of one-year adjuvant trastuzumab therapy for early-stage HER2+ breast cancer patients in Vietnam, where its reimbursement rate is 60%.
  • - A Markov model was created to compare the lifetime costs and effectiveness of trastuzumab combined with chemotherapy against chemotherapy alone, revealing that the additional cost of trastuzumab therapy leads to a high incremental cost-effectiveness ratio (ICER) that exceeds accepted thresholds.
  • - The findings suggest that trastuzumab therapy is not cost-effective in Vietnam, but significant price reductions of the drug could make it affordable, potentially aligning it with the cost-effectiveness threshold of three times GDP per capita.
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Dedifferentiation is the reversion of mature cells to a stem cell-like fate, whereby gene expression programs are altered and genes associated with multipotency are (re)expressed. Misexpression of multipotency factors and pathways causes the formation of ectopic neural stem cells (NSCs). Whether dedifferentiated NSCs faithfully produce the correct number and types of progeny, or undergo timely terminal differentiation, has not been assessed.

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The formation of a functional circuitry in the central nervous system (CNS) requires the correct number and subtypes of neural cells. In the developing brain, neural stem cells (NSCs) self-renew while giving rise to progenitors that in turn generate differentiated progeny. As such, the size and the diversity of cells that make up the functional CNS depend on the proliferative properties of NSCs.

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Introduction: The application of health economic evaluation (HEE) evidence can play an important role in strategic planning and policy making. This study aimed to assess the scope and quality of existing research, with the goal of elucidating implications for improving the use of HEE evidence in Vietnam.

Methods: A comprehensive search strategy was developed to search medical online databases (Medline, Google Scholar, and Vietnam Medical Databases) to select all types of HEE studies except cost-only analyses.

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