Potential for reversing -mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma.

For advanced oral squamous cell carcinoma (OSCC), increasing sensitivity to chemotherapy is a major challenge in improving treatment outcomes, and targeting cytoprotective processes that lead to the chemotherapy resistance of cancer cells may be therapeutically promising. Tumor-suppressive microRNAs (miRNAs) can target multiple cancer-promoting genes concurrently and are thus expected to be useful seeds for cancer therapeutics. We revealed that -mediated targeting of multiple cytoprotective process-related genes, including cellular inhibitor of apoptosis protein 1 (), can effectively increase cisplatin (CDDP)-induced cytotoxicity and overcome CDDP resistance in OSCC cells.