Background/aims: Nocturnal reflux is a largely undiagnosed and unmanaged condition predisposing to multiple esophageal complications. We evaluated the effects of rabeprazole and pantoprazole on nocturnal intragastric pH and gastric acid output during Day 1 of therapy following the consumption of standard meals.
Methods: The study had a double-blinded, randomized, two-way crossover design, and involved 15 patients with a history of mild reflux.