Publications by authors named "Phuc Chien Le"
Cytotoxic effects of the standardized extract from Salisb. rhizomes via induction of mitochondria-mediated caspase-dependent apoptotic pathway and p21-mediated G0/G1 cell cycle arrest on human gastric cancer AGS cells.
Chinh Chung Doan Thanh Long Le Nguyen Quynh Chi Ho Thi Thuy Nguyen Nghia Quang Huy Hoang Phuc Chien Le Nguyen Tu Linh Le
J Toxicol Environ Health A
December 2024
Article Synopsis
- Salisb. is a traditional herb used to treat various diseases, including gastric cancer, but its specific effects on gastric cancer cells require further investigation.
- This study explored how a standardized extract of Salisb. rhizome induces cell death in gastric cancer AGS cells, primarily through apoptosis and cell cycle disruption.
- The extract's active compounds, curdione and germacrone, were shown to affect mitochondrial function and cell cycle regulatory proteins, highlighting their potential as anti-cancer agents.