Publications by authors named "Phu M Huynh"
Article Synopsis
- Recent research challenges the traditional view of white adipocytes as merely lipid storage, revealing their crucial role in energy balance and their connection to obesity and metabolic diseases.
- The article outlines the significance of mitochondria in white adipocytes, detailing how healthy mitochondria protect these cells while dysfunctional ones can lead to obesity.
- It highlights the potential for therapeutic strategies aimed at improving mitochondrial function to promote the health of white adipocytes, encouraging "browning," and addressing obesity-related health issues.
Obesity per se is rapidly emerging all over the planet and further accounts for many other life-threatening conditions, such as diabetes, cardiovascular diseases, and cancers. Decreased oxygen supply or increased relative oxygen consumption in the adipose tissue results in adipose tissue hypoxia, which is a hallmark of obesity. This review aims to provide an up-to-date overview of the hypoxia signaling in the adipose tissue.
View Article and Find Full Text PDFThe mitochondrial stress test is a gold-standard approach for assessing adipose tissue physiological functions and pathological changes. Here, we present a protocol for conducting Seahorse assays using ex vivo mouse brown and white adipose depots. We describe steps for rehydrating the cartridge, preparing freshly harvested fat depots, placing them onto an islet capture plate, and incubating them in a non-CO incubator.
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