Publications by authors named "Phonepadith Khattignavong"
The prevalence of in humans in the Lao People's Democratic Republic (Lao PDR) has been relatively well monitored and has decreased due to effective interventions such as preventative chemotherapy with mass drug administration of praziquantel and community awareness programs. However, the prevalence among potential domestic reservoir animals remains broadly unclear, except for a few villages in the endemic area. Therefore, we conducted surveys for the domestic animals that had contact with Mekong River water.
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- - Schistosomiasis mekongi is a public health issue in Laos and Cambodia, with ongoing efforts for disease control but no complete eradication; recent studies have explored the use of loop-mediated isothermal amplification (LAMP) for detecting DNA in low-transmission environments.
- - This study aimed to create a simple LAMP assay for detecting schistosomiasis DNA in human stool and snail samples in endemic areas, using stool samples from villagers in Laos and analyzing 11,762 snail samples over three years.
- - Results showed that the LAMP assay detected a higher prevalence of schistosomiasis DNA (2.9% in stools) compared to traditional methods (0.4%), and the findings were used to develop a
Objectives: This mixed methods study was conducted to explore the barriers and facilitators for health-seeking behaviours in a malaria endemic district in Lao PDR.
Design: A convergent mixed methods design.
Setting: Two malaria endemic villages in Thapangthong district, Savannakhet Province, Lao PDR.
Background: Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao People's Democratic Republic (PDR) by 2030.
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- The study focused on understanding the migration patterns, malaria infection rates, and health-seeking behaviors of foreign migrant workers in Savannakhet province, Lao PDR.
- A total of 391 migrant workers, mostly Vietnamese men with a median age of 31, participated in the survey, with many working in factories and spending a considerable amount of time (median 405 days) in the area.
- Though no participants tested positive for malaria, 10% reported experiencing malaria-like symptoms, with most seeking treatment at healthcare facilities in Laos while largely relying on untreated bed nets for protection.
Background: The emergence and transnational spread of artemisinin resistance in Plasmodium falciparum in the Greater Mekong Sub-region (GMS) is a serious threat to malaria elimination in the region and could present a threat to malaria control in Africa. Recently, the Lao Government adopted the goal of malaria elimination by 2030, for which monitoring of artemisinin-resistant malaria within the country is indispensable. This study's objectives were to assess the distribution of k13 mutations in Laos.
View Article and Find Full Text PDFBackground: The prevalence of soil-transmitted helminth infection is high in Lao People's Democratic Republic (PDR), reaching 62% among school-children. However, this prevalence presents wide regional variations, due to differences in healthcare access and environmental factors. Curiously, there are few studies on helminth infections in pre-school children - an age group targeted by the national de-worming campaign.
View Article and Find Full Text PDFBackground: Although the malaria burden in the Lao PDR has gradually decreased, the elimination of malaria by 2030 presents many challenges. Microscopy and malaria rapid diagnostic tests (RDTs) are used to diagnose malaria in the Lao PDR; however, some studies have reported the prevalence of sub-microscopic Plasmodium infections or asymptomatic Plasmodium carriers in endemic areas. Thus, highly sensitive detection methods are needed to understand the precise malaria situation in these areas.
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