Publications by authors named "Phoebe Liddell"
Alzheimer's disease is the most common cause of dementia in the elderly, prompting extensive efforts to pinpoint novel therapeutic targets for effective intervention. Among the hallmark features of Alzheimer's disease is the development of neurofibrillary tangles comprised of hyperphosphorylated tau protein, whose progressive spread throughout the brain is associated with neuronal death. Trans-synaptic propagation of tau has been observed in mouse models, and indirect evidence for tau spread via synapses has been observed in human Alzheimer's disease.
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- The regenerative capacity of mammalian peripheral nervous system neurons is limited by slow axonal regeneration after injury, influenced by both the injury itself and external factors like exercise and enriched environments.
- Intermittent fasting (IF) might enhance axonal regeneration, influenced by the gut microbiome and the metabolite indole-3-propionic acid (IPA).
- Research shows that IPA, produced by gut bacteria, is essential for efficient axonal regeneration, promoting recovery of sensory function through immune system involvement, specifically neutrophil chemotaxis.