Publications by authors named "Phoebe Kitscha"
Activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is critical for vascular endothelial redox homeostasis in regions of high, unidirectional shear stress (USS), however the underlying mechanosensitive mediators are not fully understood. The endothelial glycocalyx is disrupted in arterial areas exposed to disturbed blood flow that also exhibit enhanced oxidative stress leading to atherogenesis. We investigated the contribution of glycocalyx sialic acids (SIA) to Nrf2 signaling in human endothelial cells (EC) exposed to atheroprotective USS or atherogenic low oscillatory shear stress (OSS).
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- Leukocyte transendothelial migration (TEM) is important for inflammation and involves white blood cells changing shape to move through blood vessel walls.
- Two proteins, ezrin and moesin, help these cells change shape, but they have different roles during this process.
- Blocking moesin affects how these cells move, but knocking down ezrin makes it really hard for white blood cells to reach the site of inflammation, showing how crucial ezrin is in helping them get there.
Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-subunit (), the gene which confers the hormones specificity for the receptor, are not known. The aim of this study was to determine if glial cells missing 1 regulates promoter activity.
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