Publications by authors named "Phoebe Ann"
Wernicke's encephalopathy (WE) is a life-threatening neurologic disorder resulting from thiamine (vitamin B1) deficiency that can be secondary to chronic alcohol abuse, gastrointestinal surgery, systemic infectious and non-infectious diseases, and chemotherapy. WE is classically characterized on MRI by reduced diffusion and T2 prolongation along the mammillothalamic tracts, periaqueductal gray and tectal plate. We present two patients with acute WE who had baseline arterial spin labeling (ASL) perfusion at the time of presentation, demonstrating increase in cerebral blood flow (CBF) within the classically involved brain regions and concurrent global cerebral cortical hypoperfusion.
View Article and Find Full Text PDFObjective: Tumor expression of Anterior Gradient 2 (), an endoplasmic reticulum protein disulfide isomerase, was associated with decreased breast cancer survival. We aimed to validate the association of tumor mRNA expression with disease-specific survival (DSS) and identify differentially expressed signaling pathways between high and low expression tumor groups.
Methods: Primary tumor mRNA expression data from the METABRIC study was used to evaluate expression as a prognostic factor for DSS while adjusting for survival-determining confounders using Cox proportional-hazards regression.
Objective: To provide prognostic information from a large cohort of women with granulosa cell tumor we analyzed the National Cancer Database.
Methods: We performed an observational retrospective cohort analysis of 2680 women with ovarian granulosa cell tumor from the 1998-2013 National Cancer Database. Kaplan-Meier and multivariable Cox proportional-hazards survival analyses were performed for the overall cohort and propensity score matched cohorts to examine the association of surgical staging and adjuvant chemotherapy with survival.
Article Synopsis
- The GI tract has a lot of a chemical called serotonin, which affects how our body works, but we don't fully understand how it is made there.
- Researchers found that special bacteria in our gut help create more serotonin by working with specific cells.
- These bacteria and their byproducts can change how we digest food and how our blood works, showing that our gut and the bacteria living in it are really important for our health.