Publications by authors named "Phiphitaporn S"
In photodynamic therapy, intermittent irradiation modes that incorporate an interval between pulses are believed to decrease the effect of hypoxia by permitting an interval of re-oxygenation. The effect of the irradiation intermittency factor (the ratio of the irradiation pulse time to the total irradiation time) on singlet oxygen formation and inflammatory cytokine production was examined using azulene as a photosensitizer. Effects of difference intermittency factor on singlet oxygen formation and inflammatory cytokine were examined.
View Article and Find Full Text PDFArticle Synopsis
- Severe septic patients in northeast Thailand face significant mortality rates, particularly with severe staphylococcal infections, where 28-day death rates reached 20%.
- Diabetes was identified as the most common underlying health issue, and while appropriate treatments were given to many patients, only a small percentage received care in an intensive care unit.
- The study found that factors such as coagulopathy and respiratory failure at the time of admission were linked to increased mortality, and plasma IL-8 levels were effective in predicting outcomes beyond the clinical variables alone.
TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis.
Clin Microbiol Infect
January 2017
Article Synopsis
- The study aims to understand how certain genetic pathways related to pathogen recognition receptors affect immune responses in Staphylococcus aureus sepsis.
- Researchers examined a specific genetic variant in the TLR4 gene and its association with cytokine responses to S. aureus in both laboratory settings and a cohort of Thai patients with sepsis.
- Findings suggest that a variant in TLR4 is linked to increased cytokine levels and respiratory failure in patients, indicating that immune responses to S. aureus share similarities with responses to Gram-negative bacteria, despite S. aureus not activating TLR4 directly.
Staphylococcus argenteus is a globally distributed cause of human infection, but diagnostic laboratories misidentify this as Staphylococcus aureus. We determined whether there is clinical utility in distinguishing between the two. A prospective cohort study of community-onset invasive staphylococcal sepsis was conducted in adults at four hospitals in northeast Thailand between 2010 and 2013.
View Article and Find Full Text PDFBackground: Melioidosis, an infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is difficult to cure. Antimicrobial treatment comprises intravenous drugs for at least 10 days, followed by oral drugs for at least 12 weeks. The standard oral regimen based on trial evidence is trimethoprim-sulfamethoxaxole (TMP-SMX) plus doxycycline.
View Article and Find Full Text PDF