Publications by authors named "Phillippe Couttet"
Article Synopsis
- - The study reports on experiments analyzing a targeted 1% of the human genome during the ENCODE Project's pilot phase, providing crucial insights into human genome function.
- - Findings reveal that the human genome is largely transcribed, with evidence showing that most genomic bases contribute to various types of transcripts, including those that do not code for proteins.
- - Enhanced understanding of transcription regulation, chromatin structure, and evolutionary insights from comparisons between species help define the functional landscape of the human genome, guiding future research in genome characterization.
We generated high-resolution maps of histone H3 lysine 9/14 acetylation (H3ac), histone H4 lysine 5/8/12/16 acetylation (H4ac), and histone H3 at lysine 4 mono-, di-, and trimethylation (H3K4me1, H3K4me2, H3K4me3, respectively) across the ENCODE regions. Studying each modification in five human cell lines including the ENCODE Consortium common cell lines GM06990 (lymphoblastoid) and HeLa-S3, as well as K562, HFL-1, and MOLT4, we identified clear patterns of histone modification profiles with respect to genomic features. H3K4me3, H3K4me2, and H3ac modifications are tightly associated with the transcriptional start sites (TSSs) of genes, while H3K4me1 and H4ac have more widespread distributions.
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