Publications by authors named "Phillip V Truong"
Article Synopsis
- Apoptosis and necroptosis are two types of cell death, with necroptosis being more inflammatory, and high glucose conditions shift the balance towards necroptosis by influencing specific signaling pathways.
- The proteins RIP1, MLKL, Bak, Bax, and Drp1 play crucial roles in mitochondrial dynamics under high glucose, where they traffic to mitochondria and activate in their phosphorylated or dephosphorylated forms.
- This study reveals that mitochondrial interactions and oligomerization of these proteins contribute to necroptosis, affecting mitochondrial function and indicating that MLKL is essential for changes in mitochondrial permeability during high glucose stress.
