Publications by authors named "Phillip Renner"
Article Synopsis
- Portal vein embolization (PVE) is used to enhance liver regeneration before surgery, but new cellular therapies show potential as alternatives.
- In a study with pigs, multipotent mesenchymal stromal cells (MSC) were infused to observe their effects on liver recovery post-portal vein ligation, simulating human surgical conditions.
- Results indicated that pigs treated with MSCs showed faster and greater increases in liver volume compared to untreated pigs, suggesting that MSCs positively influence liver regeneration through indirect mechanisms.
Multipotent mesenchymal stromal (MS) cells from adult bone marrow are a cell population that can be expanded to large numbers in culture. MS cells might be differentiated toward hepatocytes in vitro and thus are promising candidates for therapeutic applications in vivo. The efficacy of bone marrow-derived MS cells versus hepatocytes to contribute to liver regeneration was compared in a rat model of prolonged toxic hepatic injury.
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