Publications by authors named "Phillip Phung"

Article Synopsis
  • Chronic kidney disease (CKD) is a serious and costly health issue, prompting a systematic review to evaluate the cost-effectiveness of SGLT2 inhibitors for treatment.
  • The review found that both Empagliflozin and Dapagliflozin combined with standard care are cost-effective options for CKD patients, regardless of whether they have type 2 diabetes (T2D), and cost-saving for T2D patients in high-income countries.
  • However, none of the studies fully met the quality criteria for economic evaluation, indicating a need for more rigorous research in this area.
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Background: Due to the high prevalence and adverse consequences, overweight and obesity in children continues to be a major public health concern worldwide. Socioeconomic background and health-related behaviours (such as diet, physical activity and sedentary behaviors) are important factors associated with weight status in children. Using a series of height and weight assessments from the Australian Capital Territory Physical Activity and Nutrition Survey (ACTPANS), trends in prevalence of overweight and obesity by socioeconomic status were examined in ACT Year 6 school children between 2006 and 2018.

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Laboratory selection experiments are alluring in their simplicity, power, and ability to inform us about how evolution works. A longstanding challenge facing evolution experiments with metazoans is that significant generational turnover takes a long time. In this work, we present data from a unique system of experimentally evolved laboratory populations of Drosophila melanogaster that have experienced three distinct life-history selection regimes.

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Article Synopsis
  • * Our research screened 289 families for various hematologic malignancies and found that 3% had DDX41 mutations, primarily linked to MDS and AML, with some novel mutations identified.
  • * Most asymptomatic carriers of DDX41 mutations had normal blood counts, indicating that further research is needed to understand how these mutations contribute to blood cancers.
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While solutions to major scientific and medical problems are never perfect or complete, it is still reasonable to delineate cases where both have been essentially solved. For example, Darwin's theory of natural selection provides a successful solution to the problem of biological adaptation, while the germ theory of infection solved the scientific problem of contagious disease. Likewise in the context of medicine, we have effectively solved the problem of contagious disease, reducing it to a minor cause of death and disability for almost everyone in countries with advanced medicine and adequate resources.

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