Publications by authors named "Phillip Elvis"
Article Synopsis
- Dysfunction in the peripheral auditory nerve (AN) can lead to abnormal processing in the central auditory system, which is linked to heightened sound sensitivity often seen in autism spectrum disorder (ASD).
- The MEF2C transcription factor is crucial for auditory development, and its mutations can lead to a haploinsufficiency syndrome associated with ASD and related cognitive deficits.
- Research shows that a mouse model with MEF2C deficits exhibits auditory nerve impairments, highlighting cellular changes and inflammation that may contribute to both auditory dysfunction and ASD symptoms.
Purpose: Perioperative anxiety can significantly alter outcomes for pediatric patients. Parental presence at induction of anesthesia (PPIA) is one method of anxiety reduction, but the efficacy remains unclear. This systematic review and meta-analysis aimed to determine if PPIA affects child and caretaker perioperative anxiety levels.
View Article and Find Full Text PDFObjective: To examine the effectiveness of Eustachian tube procedures for the treatment of baro-challenge Eustachian tube dysfunction.
Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, databases, including PubMed (National Library of Medicine, National Institutes of Health), Scopus (Elsevier), and CINAHL (EBSCO), were searched for articles examining the effectiveness of Eustachian tube procedures for baro-challenge Eustachian tube dysfunction. Outcome measures included symptom resolution, ability to return to work, equalization problems (EP) scores, Eustachian Tube Dysfunction Questionnaire (ETDQ-7) scores, and pressure chamber testing parameters.
Cochlear Immune Response in Presbyacusis: a Focus on Dysregulation of Macrophage Activity.
J Assoc Res Otolaryngol
February 2022
Age-related hearing loss, or presbyacusis, is a prominent chronic degenerative disorder that affects many older people. Based on presbyacusis pathology, the degeneration occurs in both sensory and non-sensory cells, along with changes in the cochlear microenvironment. The progression of age-related neurodegenerative diseases is associated with an altered microenvironment that reflects chronic inflammatory signaling.
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