Functions and regulation of MUC13 mucin in colon cancer cells.

Background: MUC13 is overexpressed and aberrantly localized in colon cancer tissue; however, the specific functions and regulation of MUC13 expression are unknown.

Methods: Stable cell lines with either overexpressed or suppressed MUC13 levels were analyzed to determine cell growth, colony formation, cell migration, and cell invasion assays. The molecular mechanisms involved in MUC13 regulation were elucidated via chromatin immunoprecipitation (ChIP) and analysis of interleukin 6 (IL6) treatments.

Opting for Christian Science vs. surgical removal: a case report of a giant basal cell carcinoma arising on the back of a 66-year-old man.

Basal cell carcinoma is the most common form of skin cancer, with giant basal cell carcinoma comprising only 0.5 percent of all basal cell carcinomas. When a basal cell carcinoma is larger than 5 cm, it is designated as a giant basal cell carcinoma.