Genetic Analysis of a Large Family with Migraine, Vertigo, and Motion Sickness.

Background: Migraine is a common disorder most typically presenting as headache and often associated with vertigo and motion sickness. It is a genetically complex condition with multiple genes ultimately contributing to the predisposition and development of this episodic neurological disorder. We identified a large American family of 29 individuals of which 17 members suffered from at least one of these disorders, migraine, vertigo, or motion sickness.

Dix-Hallpike maneuver results are not influenced by the time of day of the test.

Conclusion: The result of the DH maneuver does not appear to be affected by the time of day at which it is performed. OBJECTIVE. To determine whether the time of day at which the Dix-Hallpike (DH) maneuver is performed influences the result.

A new measure of dysconjugacy in INO: the first-pass amplitude.

Background: The ratios of abducting to adducting eye movements (versional dysconjugacy index, VDI) for saccadic velocity and acceleration have been useful measures by which to objectively characterize internuclear ophthalmoparesis (INO). Amplitude measures of dysconjugacy have been less useful, given that many patients maintain the ability to ultimately reach a centrifugal fixation target and that traditional amplitude measures of VDI have focused on this 'final amplitude' (FA) position.

Methods: We utilized infrared oculography to define a new amplitude measure of dysconjugacy in 42 multiple sclerosis (MS) patients with INO.