Structure of the Hamiltonian of mean force.

The Hamiltonian of mean force is an effective Hamiltonian that allows a quantum system, nonweakly coupled to an environment, to be written in an effective Gibbs state. We present results on the structure of the Hamiltonian of mean force in extended quantum systems with local interactions. We show that its spatial structure exhibits a "skin effect"-its difference from the system Hamiltonian dies off exponentially with distance from the system-environment boundary.

Alpha-defensin binding expands human adenovirus tropism.

Mammalian α-defensins are a family of abundant effector peptides of the mucosal innate immune system. Although primarily considered to be antimicrobial, α-defensins can increase rather than block infection by certain prominent bacterial and viral pathogens in cell culture and in vivo. We have shown previously that exposure of mouse and human adenoviruses (HAdVs) to α-defensins is able to overcome competitive inhibitors that block cell binding, leading us to hypothesize a defensin-mediated binding mechanism that is independent of known viral receptors.

Alpha-defensin binding expands human adenovirus tropism.

Unlabelled: Mammalian α-defensins are a family of abundant effector peptides of the mucosal innate immune system. Although primarily considered to be antimicrobial, α-defensins can increase rather than block infection by certain prominent bacterial and viral pathogens in cell culture and . We have shown previously that exposure of mouse and human adenoviruses (HAdVs) to α-defensins is able to overcome competitive inhibitors that block cell binding, leading us to hypothesize a defensin-mediated binding mechanism that is independent of known viral receptors.

Entropy and temperature in finite isolated quantum systems.

We investigate how the temperature calculated from the microcanonical entropy compares with the canonical temperature for finite isolated quantum systems. We concentrate on systems with sizes that make them accessible to numerical exact diagonalization. We thus characterize the deviations from ensemble equivalence at finite sizes.

Assigning temperatures to eigenstates.

In the study of thermalization in finite isolated quantum systems, an inescapable issue is the definition of temperature. We examine and compare different possible ways of assigning temperatures to energies or equivalently to eigenstates in such systems. A commonly used assignment of temperature in the context of thermalization is based on the canonical energy-temperature relationship, which depends only on energy eigenvalues and not on the structure of eigenstates.

A nascent peptide code for translational control of mRNA stability in human cells.

Stability of eukaryotic mRNAs is associated with their codon, amino acid, and GC content. Yet, coding sequence motifs that predictably alter mRNA stability in human cells remain poorly defined. Here, we develop a massively parallel assay to measure mRNA effects of thousands of synthetic and endogenous coding sequence motifs in human cells.