Publications by authors named "Phillip A Geist"
Article Synopsis
- Sleep is crucial for memory consolidation, mainly through neuronal plasticity, although the exact process of how this happens is still being explored.* -
- The study used electrodes to record local field potentials in brain regions involved in emotional memory during sleep following fear conditioning, finding that theta rhythms are synchronized across regions during REM sleep.* -
- Findings suggest that the phase relationship between neural oscillations, rather than just their synchronization, plays a vital role in memory consolidation during REM sleep, challenging current theories.*
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View Article and Find Full Text PDFRapid eye movement (REM) sleep dysregulation is a symptom of many neuropsychiatric disorders, yet the mechanisms of REM sleep homeostatic regulation are not fully understood. We have shown that, after REM sleep deprivation, the pedunculopontine tegmental nucleus (PPT) plays a critical role in the generation of recovery REM sleep. In this study, we used multidisciplinary techniques to show a causal relationship between brain-derived neurotrophic factor (BDNF)-tropomyosin receptor kinase B (TrkB) signaling in the PPT and the development of REM sleep homeostatic drive.
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