Publications by authors named "Philisiwe Fortunate Molefe"
Article Synopsis
- Cryptococcus neoformans is a major fungal pathogen prioritized by the WHO, prompting research into a new multi-epitope vaccine based on its mannoprotein antigen (MP88) using computational methods.
- In the study, several promising B-cell and T-cell epitopes were identified, including specific sequences for CD8+ and CD4+ T-cells that have potential for vaccine development.
- The vaccine candidate was further developed to be stable, non-toxic, and soluble, and its genetic material was successfully cloned into an E. coli vector for potential expression and testing.
Cancer and infectious diseases such as Ebola, HIV, tuberculosis, Zika, hepatitis, measles and human schistosomiasis are serious global health hazards. The increasing annual morbidities and mortalities of these diseases have been blamed on drug resistance and the inefficacy of available diagnostic tools, particularly those which are immunologically-based. Antibody-based tools rely solely on antibody production for diagnosis and for this reason they are the major cause of diagnostic delays.
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