Age-Dependent Changes in the Production of Mitochondrial Reactive Oxygen Species in Human Skeletal Muscle.

A decrease in muscle mass and its functionality (strength, endurance, and insulin sensitivity) is one of the integral signs of aging. One of the triggers of aging is an increase in the production of mitochondrial reactive oxygen species. Our study was the first to examine age-dependent changes in the production of mitochondrial reactive oxygen species related to a decrease in the proportion of mitochondria-associated hexokinase-2 in human skeletal muscle.

Age-related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging.

Evaluation of the influence of primary and secondary aging on the manifestation of molecular and cellular hallmarks of aging is a challenging and currently unresolved issue. Our study represents the first demonstration of the distinct role of primary aging and chronic inflammation/physical inactivity - the most important drivers of secondary aging, in the regulation of transcriptomic and proteomic profiles in human skeletal muscle. To achieve this purpose, young healthy people (n = 15), young (n = 8) and older (n = 37) patients with knee/hip osteoarthritis, a model to study the effect of long-term inactivity and chronic inflammation on the vastus lateralis muscle, were included in the study.

[The gender and age characteristics of morbidity of thyroid cancer].

The thyroid cancer is the most prevalent oncologic disease of endocrine organs, characterized by multi factorial risk of development. The purpose of the study was to analyze dynamics of indices of thyroid cancer morbidity of population of the Russian Federation, considering gender and age differences in 2008-2018. The increase of "rough" indicator of thyroid cancer morbidity of male population made up to 56.

High-energy in-fiber pulse amplification for coherent lidar applications.

An Er:Yb codoped fiber amplifier chain for the generation of pulses for coherent lidar applications at a wavelength near 1.5 microm is reported. The final 1.

Modal power decomposition of beam intensity profiles into linearly polarized modes of multimode optical fibers.

We calculate the modal power distribution of a randomly and linearly polarized (LP) multimode beam inside a cylindrical fiber core from knowledge of spatial-intensity profiles of a beam emitted from the fiber. We provide an exact analysis with rigorous proofs that forms the basis for our calculations. The beam from the fiber end is collimated by a spherical lens with a specific focal length.