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Publications by authors named "Philippine Souleres"

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FAK alternative splice mRNA variants expression pattern in colorectal cancer.
Christel Devaud Anne-Françoise Tilkin-Mariamé Alix Vignolle-Vidoni Philippine Souleres Alexandre Denadai-Souza

Int J Cancer

July 2019

The Focal adhesion kinase (FAK) is a ubiquitous cytoplasmic tyrosine-kinase promoting tumor progression and metastasis processes by acting in cancer cells and their tumor microenvironment partners. FAK overexpression in primary colon tumors and their metastasis is associated to poor colorectal cancer (CRC) patients' outcome. Eight FAK mRNA alternative splice variants have been described and contribute to additional level of FAK activity regulation, some of them corresponding to overactivated FAK isoforms.

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Synopsis of recent research by authors named "Philippine Souleres"

  • - Philippine Souleres' research primarily focuses on the role of Focal Adhesion Kinase (FAK) in cancer, particularly colorectal cancer, highlighting its significance in tumor progression and metastasis.
  • - The study published in July 2019 explores the expression patterns of eight alternative splice mRNA variants of FAK and their association with poor outcomes in colorectal cancer patients.
  • - The findings indicate that the overexpression of specific FAK isoforms may contribute to enhanced FAK activity, influencing cancer progression and the behavior of both cancer cells and their microenvironment.

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